Considering the identified fragments, it is expected that four pathways (S1 S4) are involved, as shown in Fig. 9.
Alternatively, the PDR is attained 100%% for all the connections when priority mechanism is involved as shown in Fig. 3b.
On the other hand, in order to cooperate and use AlBf, both the local and cross channels are involved as shown in (6).
However, the situation is different for the second focusing peak where a scattering at the boundary of electrostatic potential created by the split gates is involved as shown in Fig. 2 b.
It is tempting to think that regional variation in chromatin structure creating more open or more closed chromatin is involved, as shown in yeasts [47], and also suggested by the differences of hotspot distribution in humans (reviewed in [48]) and mice [2], [49].
In module one, there are 10 genes that form a fully connected subnetwork and 3 seed genes are involved as shown in Figure 3. From Table S1, we can see that most of the genes in module one belong to the G protein-linked signal transduction pathway, including G protein family members FGSG_04104, FGSG_05535, FGSG_09614, and FGSG_09988.
Although we cannot exclude the intervention of multiple mechanisms, such as lysosomal defects, we found that downstream of Akt both the mTOR and FoxO3 pathways were involved as shown by the persistent phosphorylation of 4E-BP1, and the downregulation of Atg12, Bnip3 and Gabarapl1 also reversed when autophagy was reactivated.
Here, populations of cells which have been exposed to RSV during several weeks became more resistant to H2O2 and doxorubicin (known to trigger oxidative stress), and it is tempting to hypothesise that detoxifying systems are involved as shown for other potent chemopreventive molecules.
Although the majority of tau filaments in P301S tau transgenic are not ubiquitinated (Allen et al., 2002), p62/SQSTM1 may nonetheless be involved, as it has been shown to play a role in the autophagic degradation of non-ubiquitinated protein aggregates (Watanabe and Tanaka, 2011).
However, alternative proteins may be involved, as mRNA of Nfkbiz was shown to be controlled by a sequence located in the 3' untranslated region of the mRNA independently from the also present AREs [ 39].
