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We have argued elsewhere (Lai, Lombardo, Chakrabarti et al. 2013) that "both" historical/developmental and current language are likely to be key factors contributing to individual differences, and should both be investigated at multiple levels, from cognition to neurobiology.
High-throughput approaches allow today a tumour to be investigated at multiple levels: (i) DNA with copy number alteration (CNA), ii) epigenetic alterations, specifically, DNA methylation, histone modifications and microRNA (miRNA) expression level alterations, and (iii) mRNA, with gene expression (GE) de-regulation.
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To mitigate scale dependency of these methods, Poggio et al. proposed a scheme where target locations are investigated at multiple resolutions [19].
In this study, the effects of esterification of amylopectin corn starch (ACS) with FA using an n, n'-dicyclohexylcarbodiimide/4-dimethylaminopyridine (DCC/DMAP) mediated esterification reaction were investigated at multiple length scales.
The polymorphism present at the MHC genes has regularly been investigated at multiple levels of organization.
These primary cultured hepatocytes were then exposed (in duplo) to a compound and gene expression changes were investigated at multiple time points.
Overall, the paper shows that coevolutionary processes can be differentiated at surprisingly small spatial scales, and provides a novel example in which the causes of the geographic mosaics of coevolution are investigated at multiple spatial scales.
Inelastic deformation behaviour of an advanced nickel-base superalloy has been investigated at 650 °C under multiple step cyclic and dwell loading conditions and for different strain rates.
The gene expression profile of ccRCC has been investigated at the single gene level in multiple studies [5];[6] that have compared ccRCC to normal renal samples and other histological subtypes of RCC.
Multiple nonfasting testing strategies were investigated at an initial visit.
Number of prescribed medications (not including vitamins) at the time of the fall were investigated as multiple medications are a risk factor for falls (Leipzig et al. 1999).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com