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Traditionally, validation of a new identification system to be introduced in routine diagnostics consists of running parallel identifications of a large number of isolates using the new method concomitantly with set standards.
Therefore, no artificial categories such as "DOBV/SAAV" need to be introduced in routine diagnostics.
This shows the need for improved tracing of patients who interrupt clinic attendance, and suggests that such programmes should be introduced in routine care for HIV-infected children.
A monovalent group A meningococcal conjugate vaccine (PsA-TT, MenAfriVac), developed through the Meningitis Vaccine Project (MVP), is about to be introduced in routine EPI in countries of the African "meningitis belt," with a single dose at 9 months of age concomitantly administered with YF and measles vaccines [ 11].
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The yellow fever vaccine has now been introduced in routine infant immunisation programmes in the majority of regions at risk in Africa and the Americas, and emergency campaigns in response to epidemic threats have been largely successful.
However, this method has not yet been introduced in routine diagnostics or validated in different geographical regions.
Normally, new laboratory diagnostic tests are extensively evaluated and validated before they are introduced in routine clinical practice.
This could seem paradoxical since in recent years several drugs with better tolerability profile have been introduced in routine clinical practice.
During recent years the analytical sensitivities of cTnI and cTnT assays have improved remarkably to a degree that could not be expected at the beginning of the "immunoassay era," and recently, the so-called "high-sensitivity" cTnT and cTnI assays have been introduced in routine clinical practice.
Given the small sample size of our study, these promising findings warrant a larger confirmatory trial before sTLR2 levels can be introduced in the routine clinical practice.
Further studies are necessary to definitively estimate the value of these genes for prognostic marker to be introduced in WT clinical routine.
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