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Mutations can be introduced during replication by the viral proteins or also by the mutagenic processes of transfection and viral infection.
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Phase 1 mutations are introduced during replication across the G U mismatch and result in G C to A∶T transitions.
Mutations that are introduced during replication are tolerated because they are neutral for virus fitness in a particular environment, rapidly lost because they reduce fitness, or expanded because they are advantageous [ 5].
In activated B cells, A∶T mutations are strictly dependent on the Msh2/Msh6 pathway and are presumed to be introduced during patch repair by POLH, in the absence of DNA replication [9], [10].
If such sequences were introduced during TE replication, they are likely to be incomplete, and so accumulate more sequence mutations than functional genes.
The only exception is observed when an inhibitory factor c of HBV replication is introduced during super-infection.
More comprehensive projects are introduced during the course.
Moreover, unintentionally data leakage can be introduced by VM replication [20].
Sequences can be used to trace ancestry, and like base sequences, methylation at CpG sites exhibits somatic inheritance [ 13] but some errors are inevitable introduced during replication.
The National Health Service Bowel Cancer Screening Programme is to be introduced in England during 2006.
Alternatively, dI can be introduced by misincorporation of dITP in the nucleotide pool during replication [ 3, 4].
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