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β-catenin is a key effector in the canonical Wnt signalling pathway that regulates downstream gene transcription [ 50]. β-catenin levels can be intricately regulated at multiple phosphorylation sites.
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The regulatory circuitry governing this normal balancing act is must be intricately regulated in normal homeostasis, and then transiently altered to cope with injury responses.
Testicular descent is divided into a transabdominal and a transinguinal phase, which appear to be intricately regulated although not completely understood in humans.
This highly dynamic barrier is intricately regulated by myriad factors, including local oxygen tension, to both accommodate nutrient and fluid transport and exclude antigenic material [32].
Angiogenesis is intricately regulated by stimulators and inhibitors.
Eukaryotic cellular machineries are intricately regulated by several molecular mechanisms involving transcriptional control, post-translational control and post-translational modifications of proteins (PTMs).
In spite of their clinical importance, the detailed mechanism about how HSCs are intricately regulated in the molecular level remains elusive.
Plant stress responses are generally controlled by a network of specialized genes that are intricately regulated by specific transcription factors (TFs) [ 3].
We are particularly interested in DHCR24 (3β-hydroxysterol Δ24-reductase), the final enzyme in cholesterol synthesis, as it is a multifunctional protein, which is intricately regulated (reviewed in [ 1]).
Cholesterol homeostasis is intricately regulated by a battery of transcription factors among which liver X receptors (LXRs) are nuclear receptors that play a crucial role in transcriptional regulation of lipid metabolism and inflammation [1].
Results indicated that, on average, genes encoding disordered proteins are more intricately regulated than genes encoding folded proteins, while the mRNA levels of IDP genes are lower than those of ordered proteins.
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