For example, bi-level optimization, used in OptKnock [ 4], is also NP-hard [ 35], and thus can be intractable for large-scale problems.
The above problem is a combinatorial one due to the binary variable x k,n, which is intractable for large system.
It has been shown in [36] and [37] that problems of this form are intractable for large numbers of small cells and UEs, i.g., the existence of a unique optimal solution is not guaranteed.
Variants predicted to alter mRNA splicing can be validated by manual inspection of transcriptome sequencing data, however this approach is intractable for large datasets.
We also perform some simulations with very large which is intractable for classical methods.
However, the direct numerical solution of the kinetic equation is intractable for most applications due to the large number of independent variables.
The conflict in Northern Ireland had been intractable for decades.
However, explicitly listing the possibly exponentially large set of candidate transcripts is intractable for genes with many exons.
All of the above methods, however, have a possibility of being intractable for long RNA sequences.
We formalize this by means of a multi-objective optimization model that can be computationally intractable for large topologies; thus, heuristic algorithms are proposed to compute the contact plan in practice.
