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You don't know how long your business is going to be interrupted until the leak stops".
During the handover of the multicast source MN, the packets received by the multicast receiver will be interrupted until the MN attached at the new MAG successfully registers with the LMA.
In patients receiving imatinib who experience a grade 2 AE, treatment should be interrupted until the AE returns to grade ⩽1, and the dose reduced on resumption of therapy.
If the patient is hemodynamically unstable, antiplatelet and anticoagulant therapy should preferably be interrupted until the bleeding is under control and its administration is safe again, despite the higher risk of ischemic events [ 62, 72].
For safety reasons, patients will be enrolled in a 3 + 3 + 6 sequence: After registration of the first 3 patients, enrolment will be interrupted until the review of 100-day NRM and SAE reported for these 3 patients by the Data Monitoring and Safety Committee DMSCC) has confirmed safety thus justifying continuation of the trial.
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In case the body weight dropped by 10% or more, the experiment was interrupted until the monkey regained the lost weight (this criterion for interruption was not met during the course of the present experiments).
No dose reduction was required after the first appearance of a grade 2 toxicity, although treatment was interrupted until the toxicity was resolved to grade 0 1.
A list of suspension criteria was set, and the treatment of patients receiving sorafenib that met these criteria was interrupted until the toxicities were resolved.
If patients experienced grade 2 or higher nonhematologic toxicities, treatment was interrupted until the toxicity resolved to grade 0 to 1.
Subsequently, the sedative and analgesic infusion was interrupted until the patients were awake, determined based on the following three simple tasks: opening their eyes, squeezing the hand and moving fingers, and expressing discomfort.
If the toxicity recurred or grade 3 nonhaematologic toxicities, grade 4 thrombocytopenia, or febrile neutropenia occurred, S-1 was interrupted until the toxicity subsided to grade 1 or less.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com