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Most of these measured changes can be interpreted as clinically relevant outcomes with medium-to-large effect sizes.
19 Some authors have proposed that a 10% difference should be interpreted as clinically relevant.
A change in score over time of > 10 points should be interpreted as clinically significant [ 22].
The literature on the SF-36 health survey shows that very small differences on the SF-36 can be interpreted as clinically important.
In chronic pain conditions such as osteoarthritis, this modest effect size should be interpreted as clinically relevant on an individual patient basis as recommended by the IMMPACT consensus.
Furthermore, when considering the magnitude necessary for a change to be considered important, larger changes may be required at the individual level, whereas relatively smaller changes may be interpreted as clinically important when considered at the group level [ 23, 24].
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For the evaluation of the consistency of constructed clusters, we use global clinical dementia rating score which is interpreted as clinically normal CN (value 0), mild cognitive impairment MCI (value 0.5) and Alzheimer's disease AD (value 1) diagnosis for the patient.
Moderate (0.5 – 0.79) or large (>0.8) effect-sizes were interpreted as clinically relevant [ 27].
Detected organisms were interpreted as clinically relevant, of unknown significance or contaminant according to the algorithm described in Figure 1.
Thus this amount of change in self-reported HRQoL on this scale may well have been interpreted as clinically meaningful for up to 70% of participants despite it being attributable to an acute shift in response rather than a change in underlying health.
This organism is not thought to be a member of the normal microbiota, 1 and detecting even a single colony of B. pseudomallei in any specimen taken from a patient with clinical features consistent with an infective process should be interpreted as a clinically significant result.
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