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Using a phage display approach, we investigated the GMBP1 peptide, which specifically binds to the surface of gastric cancer MDR cells and exhibits the potential to be internalized into these cells and reverse the gastric MDR phenotype.
In a previous study using a phage display approach, we analyzed a peptide, GMBP1, that was specifically bound to the surface of MDR gastric cancer cells and that had the potential to be internalized into these cells and reverse the gastric MDR phenotype.
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The naked hollow gold nanoshells can be internalized into the HAECs without disrupting the cellular morphology and membrane integrity.
Our results showed that hollow gold nanoshells in the culture medium could be internalized into the cytoplasm of HAECs.
The synthesized Arg-Eu-HAP could effectively bind DNA without any cytotoxicity and be internalized into the cytoplasm and perinuclear of human lung epithelial cells.
Moreover, CCN could be internalized into the enterocytes by clathrin-mediated endocytosis pathway, and thereafter transported into systemic circulation via both portal vein and lymphatic pathway.
We therefore asked whether also 213Bi-DTPA-[F3]2 would also be internalized into the nucleus of tumor cells.
As discussed above, prior to phagosomal maturation (phagosomal acidification followed by phagosomal-endosomal/lysosomal fusion), the pathogen/particle must be internalized into the cell.
The ADR can be internalized into the cell nucleus by the diffusion.
By contrast, ADR-HSA NPs can be internalized into the tumor cells with a high positive ratio.
Therefore, most plasma proteases which are entrapped in a complex with alpha-2 macroglobulin could be internalized into the yolk together with the antiprotease.
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