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The absolute tissue oxygen saturation (StO2) has been proven to be instrumental in predicting outcome in trauma patients [ 4] but is otherwise relatively insensitive to define earlier stages of tissue hypoperfusion, despite adequate macrocirculation resuscitation aiming to prevent ischemic organ injury.
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DES was instrumental in predicting the consequences of such interventions prior to implementation, and such predictions were confirmed to be highly accurate, when compared with the actual ED.
The resulting sensitivities are instrumental in predicting the regulation of the affected reactions.
Several of these models, which faithfully recapitulate the characteristics of the human disease, have been used for pre-clinical purposes and have been instrumental in predicting therapy response in patients.
For instance, systems-level analysis of the dynamics underlying phototransduction has been instrumental in predicting novel functions of signaling proteins in the network including rhodopsin (ref. [ 16]) and in unraveling some molecular mechanisms associated to disease (ref. [ 15]).
Additionally, satisfaction was found to be instrumental in helping predict user commitment and trust that online shoppers placed on the site owner.
New mouse models could be instrumental in therapeutic development.
Calmyrin seemed to be instrumental in building this tissue canvas.
Community partners can be instrumental in the overall study design.
Environmental exposure routes can be instrumental in affecting behavior.
The optimization of hepatocyte cryopreservation has therefore been instrumental in improving the capability to predict metabolic clearance, drug drug interactions and metabolite formation in man.
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