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It has been shown that protective mechanical ventilation strategies may still be injurious in some patients with severe lung injury [ 9].
Alternatively, use of airway adjuncts such as laryngeal mask airways and repeated intubation attempts may be injurious in some patients, for example by increasing the incidence of laryngeal trauma, subsequent laryngeal edema and extubation failure.
In a rat model of acid-induced lung injury, Frank and colleagues showed that lung endothelial and epithelial injury were minimized by a reduction in tidal volume to 3 ml/kg compared with 6 or 12 ml/kg [ 17], suggesting that even a 6 ml/kg tidal volume might be injurious in some patients.
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Consider that many of the risk factors included in the FI would appear to have little in common with each other, except that they are injurious in some way.
Pro-thrombotic and anti-fibrinolytic responses, which are helpful during focal injury, may be injurious in the setting of systemic endothelial injury and are manifested by thrombocytopenia, systemic thrombosis, and multiple organ failure.
However, recent reports have shown that a Vt of only 8 ml/kg may be injurious in previously healthy mice [ 30, 35].
The Administration's penchant for deception is injurious in many ways, not least because it devalues truth as a value in public discourse.
Our results that CB2 receptor inactivation decreases mortality during CLP-induced bacterial (non-sterile) sepsis might seem contradictory to the observations in experimental allergic encephalomyelitis, allergic skin inflammation, and ischemia/reperfusion-induced inflammation in that CB2 receptor inactivation is injurious in these sterile inflammation models.
A remaining possibility, however, is that even a lung-protective ventilator strategy is injurious in the acutely injured lung.
Since then, we have learned that although mechanical ventilation is often life saving, it can also be injurious, especially in patients suffering from acute respiratory distress syndrome (ARDS) [ 1].
We are not being kind if we support someone in an endeavor that will be injurious to them in anyway -- that includes amassing college debt.
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