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Activation of the FZD and LRP5/6 receptors can be inhibited by two types of secreted proteins.
To restrain its proteolytic function, uPA catalytic activity can be inhibited by two major endogenous inhibitors: PAI-1 and PAI-2.
Our data demonstrate that PfATP4 plays a critical role in cellular processes, can be inhibited by two distinct antimalarial pharmacophores, and supports the recent observations that PfATP4 is a critical antimalarial target.
Binding of sCD4 to the covalent conjugate could be inhibited by two possible factors: (1) the presence of the peptide in its binding pocket and consequent inhibition of sCD4 gp120 interaction and/or (2) blocking of sCD4 binding resulting from partial steric hindrance by the presence of the covalently linked peptide.
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ENaC activity can be inhibited by three Nedd4-family members: Nedd4, Nedd4-2 and WWP2 [11], [12], [12].
Since the checkpoint kinase Chk1 will still be inhibited by VER-150548, this S-phase arrest would need to occur via a Chk1 independent checkpoint.
However, although TAB2 expression was found to be inhibited by miR-155 in our microarray experiments, we clearly showed that miR-155 specifically inhibited IL1-induced KGF production but did not affect the expression level of three other cytokines (CCL5, MCP1 and IL-8), indicating that in our model, miR-155 does not affect the TLR/IL1 signalling cascade.
The cAMP-dependent protein kinase catalytic (C) subunit is inhibited by two classes of functionally nonredundant regulatory (R) subunits, RI and RII.
Recombinant wild-type and mutant bovine (Bo) AChEs were inhibited by two bulky side-chain nerve agents, GF and VR, and used for conducting reactivation kinetics with five oximes.
Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, were inhibited by two derivatives with MIC values of at least 0.49 μM, whereas Gram-negative bacteria and most of the tested fungi did not display any marked susceptibility.
As anticipated, this process was inhibited by two TRPM8 antagonists: BCTC and capsazepine.
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