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Taken together, our findings demonstrate that the growth of pancreatic cancer cells can be inhibited by specific inhibition of the xc− transporter.
Many pathways are involved in resistance, mostly resulting from over-expression of growth factor membrane receptors, in particular the HER2/ErbB2 which can be inhibited by specific antibodies or tyrosine kinases inhibitors.
These CDK-cyclin complexes can be inhibited by specific cyclin-CDK inhibitors such as SIC1 and FAR1, or can be targeted for degradation by, for example, the anaphase promoting complex [32].
Because the formation of capillary-like structures on Matrigel™ by HMEC-1 cells can be inhibited by specific anti-α5β1 and anti-αvβ3 antibodies (Fig. 2C), we hypothesized that PLA2-mediated impairment of HMEC-1 adhesion and migration could also affect endothelial cell morphogenesis.
Daphnia serine proteases have been shown in-vitro to be inhibited by specific cyanobacterial inhibitors [ 19].
Bioluminescence intensity could be inhibited by specific inhibitors, SB-431542 for TGFβ or LDN-193189 for BMP.
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The synergistic effect was inhibited by specific MAP kinase inhibitors blocking the kinases p38 and JNK but not MEK1.
Schleypen, J. S. et al. Renal cell carcinoma-infiltrating natural killer cells express differential repertoires of activating and inhibitory receptors and are inhibited by specific HLA class I allotypes.
The IEC adhesion to FN was inhibited by specific antibody against the FN receptor (VLA-5), as well as competitive Arg-Gly-Asp (RGD) peptide.
Cintrofin induced neurite outgrowth from CGNs, and this effect was inhibited by specific antibodies against both gp130 and LIFR, indicating that these receptors are involved in the effects of cintrofin.
MMPs induction was inhibited by specific antibody against multimerized CD147 (Sun and Hemler, 2001).
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