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Naturally acquired CD8+ immune responses against several P. falciparum proteins have been detected (Chelimo et al, 2011; Dodoo et al, 2011; Woodberry et al, 2009), and it would be informative to find out if GAP50 is also immunogenic in humans.
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To further understand the contribution of these models, it would be informative to profile miRNAs found in adult recent thymic emigrants.
"It would be really informative to find a panel of biomarkers that's specific to each of these agents," she says.
In addition to this first set of markers, seven candidate genes (set 2) for drought and hypoxia tolerance (from 25 genes initially screened) were found to be informative in one to three pedigrees.
In all, 3193 SNPs were found to be informative and were used to create a linkage map and to scan for QTL affecting resistance to A. hydrophila.
The AL method acquires files which are found to be informative and sends these files to an expert for manual analysis and labeling {5}.
Surprisingly, most of the genes that were found to be informative for patients' metastasis were related to the immune system but not to common tumor cell characteristics such as angiogenesis, adhesion or invasion.
Only 718 SNPs, with 284 being informative, were found in genes shared only by S. Heidelberg isolates.
No loci were found to bias the results, and all loci were found to be informative.
Other sampling times need to be explored to find the most informative time, especially if different hydrolytic conditions and feedstocks are used.
In those populations that were found to be informative, the methylation pattern at the H19 ICR was shown to be compatible with maintenance or loss of imprinting and to correlate accordingly with a mono or bi-allelic IGF2 expression that could explain, at least in part, the different level of mRNA measured by RT-PCR.
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