Sentence examples for be informative of binding from inspiring English sources
ProbTF method was previously tested with predicted nucleosome locations from Segal's original model which rely on dinucleotide frequencies [1] and the nucleosome data was not found to be informative of binding sites.
Taken together, these suggest that DNA duplex stability data should be informative of binding sites; whether a lower or higher DNA duplex stability at specific TF binding sites is more preferable depends largely on the binding preference of the TF, that is, whether the TF binds to the the DNA in a double- or single-strand manner.
Four genome-level additional information sources (i.e., information at the level of individual nucleotides), evolutionary conservation, nucleosome positioning data from a recently published computational method, regulatory potential, and DNA duplex stability, are employed here to improve TF target gene prediction, which is expected to be informative of binding sites as will be discussed shortly.
Despite the fact that gene or protein expression measurements alone can be informative of transcriptional regulatory relationships and, therefore, indirectly informative of TF binding as well, we will not include those data sources into our modeling framework.
Thus, a close comparison of the ligand and receptor groups could be informative for locating missing binding partners.
Furthermore, the identification of proteolytically shed HER2 (sHER2/p95) in relation to total HER2 expression could be informative in terms of receptor activation and consequently the efficacy of Herceptin™ binding.
4) It would be informative to study the distribution of SRSF1 binding sites in the 330 likely direct mRNA targets of translational regulation by SRSF1, including those cases where both alternative splicing and mRNA translation are coordinately controlled.
Tiling ChIP-Chip array and ChIP-Sequencing technologies provide binding information of TF, which should be informative in predicting CRMs.
System-wide profiling of autoantibody repertoires can be informative.
4. Be informative and impactful.
