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The rate of cleavage can be influenced by sequence context and fold of the protein.
Indeed, phenotypic variation may be influenced by sequence variations in genes by alterations in the quality or in the quantity of the encoded proteins [ 8].
GR-1B mRNA transcript expression is driven by a unique upstream promoter region [ 48], and can be influenced by sequence variation in the NR3C1 promoter region in the human DLPFC [ 41].
Over the past few years, multiple studies [ 3- 9] have revealed that DNA methylation at specific loci can be influenced by sequence variations, such that individual genotypes at a given locus may result in different patterns of DNA methylation due to allele-specific methylation.
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However, the temporal pattern of expression as seen in transgenic mice should be confirmed on the endogenous target at different stages of development (not only in adult cortex and e12.5 mammary glands), since it could be influenced by sequences near the insertion site.
Pseudogene assignments were not exhaustive and were based on the available sequence; they may be influenced by sequencing artifacts due to the draft nature of the genomes.
The S-cdG·dA mismatch is distinct from the dG·dA mismatch as dG·dA mismatch pairs are influenced by sequence and pH.
The present study demonstrated that Tac and CsA pharmacokinetics are influenced by sequence variants in several genes.
Since BLAST scores are influenced by sequence match length, shorter sequences will produce lower scores, and may also be more likely to represent assembly artifacts or truncated transcript models.
Nucleosomes can be assembled by genomic DNA and recombinant histones in the absence of cellular influences; therefore, in vitro nucleosome occupancy is affected mainly by the intrinsic specificity between a histone and the DNA sequences, whereas in vivo occupancy is influenced by sequence preferences, TFs and chromatin remodelers [ 5, 13, 20].
Indeed, the occurrence of APA is influenced by sequencing depth (Wu et al. 2011; Shen et al. 2011).
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