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Furthermore, the ability to correctly model Ks variability across sites may reveal novel insights into the functional constraints acting on the DNA and RNA levels, which cannot be inferred using standard codon models.
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A more distressing lower bound, also in the same paper of King et al., shows that any distance-based method requires Ω (n 2 log n ) time to reconstruct correct trees where a simple Markov model of evolution is assumed, and distances are inferred using standard techniques, assuming sequences are quite short.
Haplotypes will be inferred using a Bayesian method (PHASE).
Haplotypes will be inferred using the PHASE software package [ 97].
Haplotype phase and an estimate of the population frequency distribution of the haplotypes are inferred using a standard EM algorithm with a partition-ligation approach for blocks with greater than 10 markers.
Slopes and standard errors were inferred using the maximum likelihood estimation method described by Clauset, Shalizi and Newman [38].
Lake acidity was inferred using a diatom inference model.
Gene trees were inferred using the PTHREADS version of RAxML 8.1.2 (ref. 58) using the PROTGAMMAWAG model and the standard algorithm.
Ancestral amino acid states were inferred using parsimony.
Thumb movements are inferred using data from the other sensors.
Branch supports were inferred using 100 bootstrap replicates.
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