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This is in contrast to indirect cooperativity, i.e. fuzzily spaced co-binding of any TF pairs, which can be inferred by several existing bioinformatics approaches [ 6- 9].
HGT among distantly related bacteria can be inferred by several approaches [ 33], but these are difficult to apply when bacteria as closely related as B. cereus sensu lato are investigated [ 34].
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ND10's defensive role in the infection process can be inferred by the fact that several herpesviruses are required to disrupt it.
That TFs with similar function regulate similar targets in the network can be inferred by the presence of several established cooperating TF clusters, such as Ace2/Swi5, Fkh1/Fkh2/Mcm1 and Swi4/Swi6/Mbp1.
Despite the numerous gaps, the linear order of several contigs could be inferred by combining repeat analysis, comparative genomics and use of low-quality 454 sequences, as follows.
The role and origin of several repeat families could not be inferred by homology.
Because atoms are so minute, their properties must be inferred by indirect experimental techniques.
But as doctors now understand it, intent could be inferred by the degree of dilation they induce in their patients.
Involvement of Filamin in signal transduction is inferred by its interaction with several components of the NF-κβ pathway and with the small GTPases RhoA, Rac, Cdc42 and RalA, and also with regulators and effectors of small GTPases like Trio, FilGAP, PAK1 and ROCK, and β1 integrin [17] [21].
Increased autophagy is inferred by the presence of PI3K pathway members and several autophagy-related protein (Atg) encoding genes.
Consequently, several combinatorial regulations and regulations by corticosteroid were inferred by extending the original network.
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