Sentence examples for be ineffective in blocking from inspiring English sources

Although KRAS is downstream to EGFR, EGFR-TKIs have shown to be ineffective in blocking the activities of mutated KRAS protein [25].

More recently, RU 38486 was shown to be ineffective in blocking acid- mediated protein degradation as its action is only an indirect one, mediated via insuline- like growth factor I (IGF- I)[ 24, 46].

Finally, the other two 5-LOX inhibitors, 5,6-DAA and zileuton, were ineffective in blocking TRPM7 currents.

Inhibitors of 12-LO X(baicalein) and 15-LOX (PD146176) were ineffective in blocking TRPM7-dependent cell rounding (Fig. 1A,B).

More interestingly, temperature shifts applied later than 15 min following pI division were ineffective in blocking the N-response.

Interestingly, 3 mM HEPES was ineffective in blocking these transients: i.e. the transients did not significantly differ from those measured in bicarbonate Ringer's solution [19].

We found that both selectively blocked IK (DTX with IC50 = 163.9 nM and Hill slope 0.7, MTX with IC50 = 180.7 nM and slope 0.5), while they were ineffective in blocking IA (Fig. 4v, Fig. S1).

Although MO is ineffective in blocking maternal protein activity, it is advantageous for allowing embryos to pass through the early cleavage period in the presence of MOs targeting cytokinesis-essential genes like Drfs.

Several publications have indicated that caspase inhibitors are ineffective in blocking neutrophil apoptosis, and have concluded from this that caspase independent apoptosis pathways are implicated in limiting neutrophil lifespan [22], [23], [30].

A higher concentration of CE (30 μM) was ineffective in blocking relaxation in 4 month high fat diet ApoE−/− aortae.

When h32-140 α-syn pffs were added to C1 and Syn303 to C2, Syn303 was ineffective in blocking α-syn pathology elicited by h32-140 pffs in C1.