Sentence examples for be ineffective in activating from inspiring English sources
Med was found to be ineffective in activating ERK1/2 and GSK-3 β, although there are reports suggesting that ROS can lead to induction of ERK1/2.
As AP-evoked [Ca2+]i transients in the spines remain at high levels for just several milliseconds they should be ineffective in activating the Ca2+-myristoyl switch of hippocalcin (Fig. 7C).
The results showed that zfPRL1 or zfPRL2 were ineffective in activating the zfGHRs (Figure 6C).
Overall, this suggests that rTFs containing fingers targeting TFLO11/F1 were ineffective in activating the expression of FLO11 in vivo.
Remarkably, IL-1 treatment was ineffective in activating the expression of Nfkb2 mRNA in WT MEFs, despite the early induction of Nfkbia (bottom, Figure 5A).
T-cell receptor engagement alone is ineffective in activating the pathways needed to produce the proinflammatory cytokines and other growth factors required for the induction of the pathogenic autoimmune response.
Other tyrosine analogs were ineffective in stimulating hydrogenase activation.
In colorectal cancer, it has been shown that treatment with Cetuximab, an inhibitor of EGFR, is ineffective in the presence of an activating mutation of k-ras, a downstream protein in the EGFR signaling pathway [ 41].
In C57BL/6 and LPA1 knockout mice exposed to 15 Gy gamma irradiation, orally applied OTP reduced the number of apoptotic bodies and activated caspase-3 positive caspase-3 positivefecells in LPA2 knockout mice.
Lastly, in vitro data suggest that heregulin-induced HER2 HER3 heterodimers mediate trastuzumab insensitivity by activating signaling through the AKT mTOR pathway, and that trastuzumab is ineffective in abrogating this signal [ 13].
