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However, boundaries can be induced to migrate by externally applied forces such as those due to stress or by magnetic fields.
We hypothesize that in order for effective cartilage integration to take place, matrix-free chondrocytes must be induced to migrate between the two tissue surfaces.
Objective We have previously shown (Hunziker and Rosenberg, J Bone Joint Surg 1996 78A 721 33) that synovial cells can be induced to migrate into partial-thickness articular cartilage defects, therein to proliferate and subsequently to deposit a scar-like tissue.
We used NBT-II epithelial cells that can be induced to migrate when plated on collagen.
In addition, cells that can be induced to migrate from adjacent bone marrow structures may contribute to the local facilitation and propagation of inflammation and bone damage.
To test this possibility, we employed the simple wound-healing assay in which cells will be induced to migrate and fill the space created by scratching.
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Since NBT-II carcinoma cells are induced to migrate on collagen substrates [ 30], cells were labeled with S-methionine/cysteine mix and chased on plastic or collagen for 18 h in the presence or absence of lactacystin.
In vitro studies also show that YKL-40 promotes chemotaxis, cell attachment, spreading and migration of vascular endothelial cells which suggest a role of YKL-40 in the atherosclerotic plaque formation, where smooth muscle cells are induced to migrate through the intima in response to exogenous signals [ 20].
YKL-40 promotes chemotaxis, cell attachment, spreading, and migration of vascular endothelial cells, suggesting that YKL-40 promotes the process of atherosclerotic plaque formation, in which vascular smooth muscle cells (VSMCs) are induced to migrate through the intima in response to exogenous signals (13).
YKL-40 promotes chemotaxis, cell attachment, spreading, and migration of vascular endothelial cells, suggesting that YKL-40 promotes the process of atherosclerotic plaque formation, in which vascular smooth muscle cells (VSMCs) are induced to migrate through the intima in response to exogenous signals [ 7].
Under the mechanical environment of knee joint, the subchondral bone is induced to migrate from surrounding bone part into the defect center (as illustrated in Figures 4, 5, 6, and 7, as evidenced by the cartilage tissue underlying the migrated subchondral bone), which in turn becomes maturation gradually.
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