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The observations suggest some element of neurodegenerative disease and brain abnormalities may be induced through an epigenetic transgenerational mechanism.
Second, kidney apoptosis can be induced through an effect on both global and regional renal blood flow.
In addition, proliferation in the IKMV ducts could be induced through an indirect mechanism, mediated by NF-κB-driven production of pro-inflammatory factors.
As reported in the literature, the thermoshrinking type of demixing of hydrogels in water might be induced through an aggregation of polymer segments due to hydrophobic interaction [ 34].
While it is reasonable to assume that the compounds identified by this approach induce ARE activity through oxidative stress, it might be possible that Nrf2 can be induced through an unrelated mechanism.
Aside from this high occurrence, the zebrafish model has another relevant advantage over mice, with respect to the evaluation of fibrosis development according to reproductive stages – the occurrence of ovarian senescence in zebrafish is spontaneous, whereas in mice it has to be induced through an ovariectomy (Gopalakrishnan et al., 2013).
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The condition can be induced through a number of triggers including listening to a certain voice, sounds or personal attention.
Mania-like behavior, such as hyperactivity (Giros et al. 1996; Ralph et al. 2001) and sensorimotor deficits in PPI (Ralph et al. 2001), can also be induced through a complete knock-out of the DAT gene in mice.
Apart from the inflammasome, IL-1 secretion by macrophages in contact with MSU can also be induced through a TLR-dependent mechanism [ 5].
Negative effects on the CNS mediated by CXCL12 could be induced through a direct action on dopaminergic neurons expressing CXCR4 or the release of cytokines from microglia [ 18, 19].
CRF, ACTH, and cortisol release can be induced through a number of different agents, including glucose-depriving medications such as insulin (Costa et al. 1996) or 2-deoxyglucose, nicotine (Matta et al. 1998), and alcohol itself.
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