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In these rats a phenotype very much resembling RA in human can be induced by injecting an agent such as collagen, pristane, oil or adjuvant [ 3].
Arthritis can be induced by injecting serum from K/BxN T cell receptor (TCR) transgenic mice into normal mice, reflecting the high concentrations of arthritogenic autoantibodies recognizing glucose-6-phosphate isomerase (GPI) in the K/BxN arthritis model.
Muscle degeneration and regeneration can be induced by injecting bupivacaine [ 15], the venom of Australian tiger snake [ 16], and cardiotoxin [ 10- 17, 18] 18] from the Taiwan cobra (Naja naja atra) directly into rat muscle.
The same disease can be induced by injecting mice with heart proteins mixed with adjuvant(s), which indicates that an active infection is not necessary for the development of autoimmune disease.
Indeed, it is hard to believe that very high doses of single cytokines, causing significant systemic toxicity can act independently alone but are probably inducing a cytokine storm which could probably be induced by injecting a highly infectious, dangerous agent and this of course brings Cooley's toxins to mind!
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Twenty-four hours after the last CPE injection, each female ovulation was induced by injecting a DHP-solution and then transferring them to a new closed recirculating aquaculture system, where they were maintained for 16 h with spermiating males (sex ratio 4/1) in order to obtain spontaneous reproduction.
To address the role of CXCL12/CXCR4 signaling in normal micturition and inflammation-induced bladder hyperreflexia, bladder inflammation in adult female Wistar rats was induced by injecting CYP intraperitoneally at acute (150 mg/kg; 4 h), intermediate (150 mg/kg; 48 h), and chronic (75 mg/kg; every third day for 10 days) time points.
Abdominal sepsis was induced by injecting autologous feces into the peritoneal cavity.
In brief, general anesthesia was induced by injecting 6 mg × kg−1 tilétamin-zolazepam intramuscularly.
Sepsis was induced by injecting 1.5 g/kg of autologous feces into the abdominal cavity (T0h).
Diabetes was induced by injecting STZ (100 mg/kg) intraperitoneally to two days old pups.
More suggestions(15)
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