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Our current findings are entirely consistent with the previous study, but suggest, firstly that lamin A controls this pathway and secondly, that invasiveness can be induced by expression of T-plastin through the same mechanism.
Furthermore, abnormal centrosome function can be induced by expression of the papilloma virus genes E6 and E7, inhibiting normal TP53 and RB1 activity, respectively (Duensing et al, 2000).
This effect on cell death can also be induced by expression of the bone morphogenetic protein (BMP) family: Msx2 and p21 are induced following BMP4 treatment, and both molecules are necessary for BMP4-mediated cell death to occur in several cell types [ 21, 22].
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Mouse RMS tumors were induced by expression of oncogenic Kras(G12v) and disruption of CDKN2A (p16p19) using ex-vivo transduction and intramuscular injection of transduced mouse satellite cells.
Vesicle formation is induced by expression of wild-type caveolins, but not caveolin mutants defective in caveola formation in mammalian systems.
A similar phenotype is induced by expression of constitutively active Rac1, and TCR signaling activates Rac1.
The disruption of Epstein-Barr virus latency in B cells is induced by expression of BZLF1 immediate-early protein, and this transcription is negatively regulated by YY1 [227], [227].
Strikingly, 93% of the mRNAs downregulated in PCaDCL were induced by expression of NKX3.1 in LH cells (Supplementary Table 1).
However, PGC markers were undetectable in animal caps that had been induced by expression of Activin A. We then used low levels of Activin A (1 pg) or FGF (3 pg), concomitant with BMP4 (5 ng).
For this purpose, we used the MMTV-PyMT murine model whose oncogenesis is induced by expression of the polyoma virus middle T oncoprotein under control of the Mouse Mammary Tumour Virus (MMTV) promoter (PMID: 1312220).
There are 14 subtypes of type-1 IFNs, and a plethora of other secreted soluble factors can be induced by MAVS expression.
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