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However, genetic lesions can also, themselves, be induced by abnormal cell interactions initiated by extrinsic carcinogenic agents such as chemicals, viruses, hormones and radiation.
Knocking out of Dicer1 induced the high expression of mouse transposon (MT and SINEelementsts B1 and B2 (Murchison et al., 2007), which may be induced by abnormal DNA methylation pattern in Dicer1 null oocytes (Jeong and Lee, 2005).
In this injury model, cartilage degeneration will be induced by abnormal stress due to joint instability.
The observed defective response inhibition in EphA3KI/KI mice, corresponding to an ADHD phenotypic feature, could be induced by abnormal catecholamine levels (van der Kooij and Glennon 2007; Sontag et al. 2010).
For example, injury of mesopontine cholinergic neurons in PPT and LDT can be induced by abnormal β-amyloid peptide expression in transgenic mice and appears to be associated with REM sleep perturbations relevant to AD (Zhang et al., 2005).
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The deterioration in grain quality was induced by abnormal starch accumulation under elevated ozone levels as well as by high-temperature stress.
Epilepsy is a group of chronic brain diseases characterized by the transient dysfunction of the central nervous system that is induced by abnormal discharge and threatens human health.
In addition to motor function deficits and bladder dysfunction, neuropathic pain is also a common and debilitating symptom in SCI patients which is induced by abnormal neuronal activities in the spared tissue surrounding the lesion site.
The 'bone contusion' theory suggests that SBCs originate from the necrotic lesions in subchondral bone, which are induced by abnormal mechanical stress and subsequent microcracks, edema and focal bone resorption [ 116].
Previous studies have already suggested that brain plasticity changes can be induced by early abnormal viusal experience, such as strabismus.
Thus elevated NEK2A in cancer cells may be induced by those abnormal conditions.
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