The modeling system itself is comprised of two basic components: the modeling infrastructure (PyBioS) and the model itself – ModCell™ – which can be individualized with data from a single patient, and then explored, using the tools provided by PyBioS [ 85] to create the ModCell™ systems biology integrated platform (Fig. 2).
Pressure may need to be individualized, with higher airway pressures required to generate an equivalent transpulmonary pressure in the patient with increased intra-abdominal pressure.
They should be individualized with objective and the most accurate individual prognostication, taking into account all the relevant clinical characteristics [ 17].
Nevertheless, their use should be individualized with caution.
In light of such a complex picture, it looks more appropriate that antidiabetic therapy to be individualized with respect to risk-to-benefit ratio.
The Canadian Diabetes Association Clinical Practice Guidelines provide recommended targets for glycemic control and suggest that treatment strategies should be individualized, with consideration given to presence of risk factors.
However, the use of laxatives must be individualized with special attention to cardiac and renal co-morbid conditions, drug interactions, and side effects particularly in the frail elderly [ 22, 62].
In the elderly, use of laxatives must be individualized with special attention to patient's medical history (cardiac and renal co-morbid conditions), drug interactions, costs, and side effects.
However, in our clinical experience, we found that the treatment regimen has to be individualized with close follow-up due to the varying degrees of inflammation and pain tolerance in each patient.
In sum, scheduled telephone visits were viewed as potentially beneficial for routine care not requiring physical examination, and patients and providers suggested using them to evaluate need for in-person care; however, visits would need to be individualized, with patients able to discontinue if not satisfied.
