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PINCH and ILK have been shown to be indispensable for proper control of cell shape change, motility and survival [ 13].
Further evidence of the interconnection between circadian oscillators and metabolism stems from several recent studies on the core clock gene Rev-erbα (also known as Nr1d1), which has been found to be indispensable for proper lipid and carbohydrate metabolism [ 9– 11].
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Although these latter substances also are indispensable for proper bodily functions, almost all of them can be synthesized by animals in adequate quantities.
Intravascular catheters are widely used and are indispensable for proper patient management.
The present study indicates that normal development of the supporting cells is indispensable for proper cellular function of the OHC.
Vitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects on viability and apoptosis of neurons remains unknown.
Faultless transport of rhodopsin from the photoreceptor cell body to the light sensitive membranous compartment of the eye is indispensable for proper visual function and eye development [6], [7].
Mutations in these lrx genes induce growth phenotypes implying that LRX proteins are indispensable for proper plant development.
They are indispensable for proper tissue identification and differentiation, participation in intercellular communication and signaling, and cell function regulation [ 12– 15].
It is well known that cilia have important roles in a variety of signaling pathways which are indispensable for proper development or metabolism [ 39].
These results strongly suggest that there is a critical interaction between Shh and canonical Wnt signaling during craniofacial development, and this is indispensable for proper lip formation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com