Phospholipids are indispensable for normal structure of membranes.
Here, we demonstrate that BCL11A is indispensable for normal HSC function.
Changes in cytosolic Ca2+ are indispensable for normal cell function [1].
Moreover, Capzb2 - βIII-tubulin interaction is indispensable for normal growth cone morphology and neurite length[9].
Dicer1 is indispensable for normal pancreatic cell differentiation at embryogenesis [11].
Retinoic acid (RA), the active metabolite of vitamin A, is indispensable for normal morphogenesis and organogenesis of most vertebrate species.
Actin and tubulin are indispensable for normal neurite development and regenerative responses to injury and neurodegenerative stimuli.
Previous study showed that Dicer1 is indispensable for normal development of the pancreas [11]; however, its function in the adult pancreas had not been elucidated.
The finding that inhibition of VCP expression promotes apoptosis [44] suggests that intact VCP is indispensable for normal development and cell survival.
For example, five testicular protein kinases,TSSK1, TSSK2, SSTK, CAMK4, and Haspin, are specifically expressed in haploid germ cells and two of these enzymes (CAMK4 and SSTK) are indispensable for normal progression of spermatogenesis and male fertility [13], [14], [15], [16].
