Additionally, one has to take into account that MTX causes the differential expression of many genes that may be direct or indirect regulators of cell proliferation, survival or apoptosis, and that this expression pattern can contribute to modulation of the resistance phenotype.
Although follow-up studies and literature searches suggest that PRKCI is an indirect regulator of the signaling pathway, additional studies will be required to confirm the precise mechanism of HSF1 regulation.
Simplistically, two broad mechanisms of protease action may be imagined; proteases may act as indirect regulators of egress by activating distinct effector proteins or signal transduction pathways.
They are however of interest as potential indirect regulators of gene expression [18].
The underlying assumption is that such eQTL regions contain direct or indirect regulators of the target gene in question.
FXR activation is also an indirect regulator of the structure of the microbiome through the BA induced FXR-dependent expression of anti-microbial peptides.
The effect of the Pho regulon on induction of the acid resistance response is likely to be indirect, since no putative Pho box es) were found upstream of these regulators.
We find that Spo0A affects the expression of several regulators (Additional file 3), suggesting that many of the observed effects may be indirect.
Some of these may be indirect associations.
