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Failure to modulate activity in response to changing task demands may be indicative of dysfunction, even when associated with a pattern of high activity across conditions.
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Furthermore, the accumulation of aberrant storage material is reminiscent of features described in many lysosomal storage diseases (LSDs) and is indicative of dysfunction along the endosomal/lysosomal pathway.
Both groups achieved a conduct problems score in the normal range (scores >3 are indicative of dysfunction), but girls in the high-DHA group scored significantly higher compared with girls in the standard-DHA group (see web appendix B).
The large down regulation of these genes may be indicative of mitochondrial dysfunction in DM dogs.
Thus, decreased plasma LCFA may be indicative of hepatic dysfunction in HIV patients.
Findings from our study show poor immunological recovery following delayed ART, which could be indicative of possible dysfunction of the microvascular endothelial cells of the bone marrow.
Theoretically, a reduction in vascular response in ACh alone, with no concurrent reduction in SNP response, would be indicative of endothelial dysfunction.
Reactive astrocytes and microglia often accompany neuronal loss and might be indicative of neuronal dysfunction (Gehrmann et al., 1995; Macauley et al., 2011).
Elevated levels of fetal cell-free DNA may be indicative of underlying placental dysfunction, which has been associated with preterm birth.
This lack of significant increase despite a significant increase in fat mass would be indicative of adipose tissue dysfunction.
Gene expression dysregulation may be indicative of imbalance or dysfunction in these biological pathways and therefore, implicate potential drug targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com