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As disturbances in electrolyte homeostasis accompany the development of high blood pressure in PHA2 patients carrying WNK1 mutations, we hypothesised that variation in serum and/or urinary electrolytes would be indicative of altered WNK1 function or expression, and this may help to identify polymorphisms that also affect BP.
Similarly, a change in the LH to testosterone ratio may be indicative of altered receptor function or steroid synthesis.
Enrichment for pathways involved in metabolism and internal and external cell structure (e.g., actin cytoskeleton and integrin signalling) may be indicative of altered islet function and architecture.
It has been hypothesised that these changes are indicative of neurodevelopmental delay in these fetuses, however they might just as likely be indicative of altered metabolic environment [ 62].
Finally, the trend towards decreased PB pDC numbers in the OA patients, although not significant, may be indicative of altered DC migration toward the synovial compartment.
Transcript levels of the majority of NBS-LRR-encoding and related genes were not altered during the plant defense response or by treatments with plant defense signaling molecules; however, the expression of several genes was altered and may be indicative of altered levels of surveillance by the plant.
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A reduction in milk fat concentration of de novo and 16-C FA and a marginal elevation in trans-10 C18:1 in Ca-FA is indicative of altered ruminal biohydrogenation and increased risk of milk fat depression.
The hyperleptinaemia observed in both males and females is indicative of altered adipocyte function and increased adiposity, however, increased fat deposit were not always associated with high leptin levels.
These changes are indicative of altered amino acid metabolism, oxidative stress and pyrimidine turnover in the transformed kidney.
There was no evidence for the formation of novel bands within the smear of ssDNA products, which would have been indicative of altered or relaxed Chi-recognition specificity.
To determine if the observed changes in mRNA abundance were indicative of altered transcription factor activity, we performed transcription factor binding site (TFBS) enrichment analysis.
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