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The abundance of electron-dense vesicles and deposits might be indicative of alterations in the transport of membranous organelles in SPG11-dNeurons (20).
We hypothesised that the expression of mutant matrilin-3 and COMP would induce changes to the extractability of other cartilage components, which would be indicative of alterations to the anchoring or associations of individual molecules and the overall functional properties of the tissue.
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Changes in the light scattering intensity (LSI) of polymer solutions are indicative of alterations in the molecular weight and/or in the radius of gyration, i.e., the dimensions and shape of the macromolecules.
We have shown previously that these changes are indicative of alterations in regional perfusion [ 18, 19].
Spectral analysis has shown that the hydroxyapatite collagen ratio (mineral volume fraction), carbonate apatite:hydroxyapatite ratio (carbonate substitution), and amide III (protein conformation) are altered in subchondral bone from the hip joints of patients with OA (18), all of which are indicative of alterations in bone composition and the collagen secondary structure.
It has been reported to be indicative of the alterations that the airflow pattern exhibits regarding the speech production under atypical circumstances.
If so, misregulation of homeobox genes during neoplastic progression may be indicative of progressive alteration of epithelial cell identity.
The contrasting AGP and Hp/SAA responses could be indicative of an alteration in the output of cytokine from these different sites.
In sum, the observed histone changes may be indicative of the alteration in chromatin structure and gene expression in the kidneys of stroked rats.
The fact that its binding to aggregates leads to creation of unstructured oligomeric species may be indicative of an alteration in the heat shock response.
Overall, these growth alterations could be indicative of underlying functional, physiological alterations which could become apparent in postnatal life.
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CEO of Professional Science Editing for Scientists @ prosciediting.com