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This further strengthens the notion of a functional interaction between these two proteins and suggests that high JAG2 level may be indicative of aggressive MB tumors.
Clinical application of the AccuCyte – CyteFinder system was also demonstrated in an evaluation of CTCs in a patient with advanced triple-negative breast cancer; here we demonstrated application of biomarkers for proliferation (Ki-67) and drug targeting (Her2), and observed cell clusters, which have been reported to be indicative of aggressive disease [ 16, 17].
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This study also showed that elevated serum HER-2/neu levels before first metastasis were indicative of aggressive disease.
As with the combined gene models, a score lower than the cut point is indicative of aggressive disease.
Furthermore, if we limit our analysis to advanced stage of CRC (Stage IV), ALK amplification showed significant association with poor differentiation, which is indicative of aggressive phenotype.
The presence of the translocation may be indicative of local aggressive behavior, but a larger cohort may be required to show statistical significance.
Tumour necrosis reflects the presence of hypoxia, which can be indicative of an aggressive tumour phenotype.
Cox-2 expression has been reported to be indicative of an aggressive breast cancer phenotype that is resistant to doxorubicin [ 11].
The increased expression of genes involved in cellular proliferation and cell motion may be indicative of more aggressive tumours leading to decreased survival rate.
The clinical course is one that does respond very well to chemotherapeutic intervention with an overall excellent prognosis despite clinical and h stomorphologic features that could be indicative of a more aggressive clinical course (i.e., the degree of angioinvasion and large cell transformation).
While that would seemingly be indicative of a more aggressive stance by Trump, one official described the raid and the proposal as an outgrowth of earlier Obama-era operations that have pushed al-Qaeda militants from their sanctuaries and provided more opportunities for U.S. strikes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com