SIRT3 levels are increased in multiple tissues during nutrient stresses such as DR. DR is associated with increased lifespan (Anderson & Weindruch, 2010), as is a SIRT3 allele with increased activity (Bellizzi et al., 2005).
Using structure-guided design, the potency of enzyme inhibition was increased in multiple isozymes from different bacterial species.
miR-155 demonstrates an average of 50-fold increase in expression in CLL cells tested compared with control B cells (Figure 2D), is increased in multiple cancers [27], [28], [40], and promotes B cell lymphomagenesis [41].
Because the expression and activity of GRK2 are increased in multiple animal models of heart disease and in human heart failure, it has been suggested that enhanced GRK2 activity can explain the concomitantly decreased receptor responsiveness[24].
Importantly, HA deposition is increased in multiple fibrotic diseases.
Bone marrow angiogenesis is increased in multiple myeloma and has prognostic importance.
A reduction in overall collagen content and were seen in RCD; type II and III collagen content were increased in multiple studies.
RNA expression of these three genes was increased in multiple cell culture and xenograft experiments, consistent with increased FOXO1A/FOXO3A and decreased MYC transcriptional activity (Additional file 6 Figure S2).
We found that expression of all three reporters was increased in multiple tissues, most notably in the intestine, in 3-day-old animals subjected to pat-4/ILK RNAi from day 1 of adulthood (Fig. 2A D).
Transcription of the TGFβ superfamily cytokine GDF15 (growth differentiation factor 15) is increased in multiple solid tumors, where it promotes tumor growth and confers resistance to several drugs such as bortezomib.
