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FasL mRNA expression has also been reported to be increased in malignant cholangiocytes compared with the low levels detected in non-malignant cells [37].
MMP activity appeared to be increased in malignant prostatic tissue compared with BPH.
In the case of breast cancer, SR-BI protein levels were found to be increased in malignant tissue samples compared with the normal surrounding tissue [ 30].
The PKCα and PKCε activity levels seem to be increased in malignant gliomas and mechanisms related to tumor cell invasion, and metastasis is activated [ 47, 48].
Several of these biological properties are shared by CCN3 whose expression was reported to be increased in malignant tumors, to interfere with adipocitic differentiation, and to be involved in the tumorigenic phenotype of CML.
In contrast, CCL2 expression has been found to be increased in malignant glioma (Kuratsu et al, 1993; Takeshima et al, 1994), primary and metastatic melanoma (Graves et al, 1992) and glioblastomas and astrocytomas (Desbaillets et al, 1994) compared to corresponding normal tissues.
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Tau is increased in malignant gliomas in correlation to the stage of cell proliferation and the presence of oedema [50].
Conclusion: Oxidative stress is increased in malignant pleural effusion malondialdehyde and superoxide dismutase being oxidative stress markers, can be used for differentiating between malignant and benign pleural effusions.
All of these four PET parameters were increased in malignant lesions, and the same patterns were observed in the subgroup analysis of gastrointestinal cancer.
Data from patient tissues has suggested that the relative expression of KLK2 is increased in malignant tissue compared to benign and healthy prostatic tissue, and the intensity of hK2 immunostainings in, e.g., lymph node metastasis correlates better with PCa tumor grade than that of PSA [13, 14].
These results indicate that Wnt5A expression is increased in malignant compared to benign human prostate.
More suggestions(15)
be increased in other
be altered in malignant
be misused in malignant
be studied in malignant
be increased in several
be implicated in malignant
be increased in future
be cleaved in malignant
be seen in malignant
be demonstrated in malignant
be found in malignant
be dysregulated in malignant
be increased in exceptional
be increased in nonvalvular
be increased in good
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