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Our laboratory previously found HO-1 to be increased in human lung allografts with acute cellular rejection (ACR) and in active obliterative bronchiolitis.
Unlike our results, Wnt2 was reported to be increased in human non-small cell lung cancer tissues [33].
Also oxidative stress could be increased in human fibroblasts by the application of VLCFA [53].
MSX2 expression has been reported to be increased in human ovarian endometrioid adenocarcinoma as a target of WNT signaling [ 29].
However, Beclin-1 expression was reported to be increased in human colon, gastric, and pancreatic cancers, in contrast to their normal counterparts [ 17, 18].
Some of these cholesterol oxides (or oxysterols) were shown to be increased in human cataractous lenses [ 10], 7-ketocholesterol being the predominant oxysterol present in human cataracts.
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This may then have consequences for disturbed sleep wake patterns during later life and for adverse neurologic sequelae known to be increased in humans born with growth restriction.
This protein was also found to be increased in humans following a marathon run but returned to basal levels within a few hours [ 71].
Levels of PBDEs also appear to be increasing in human tissue, according to a review published in the May 2000 issue of EHP.
Expression of TLR4 and its coreceptors MD2 and CD14 is increased in human lesional SSc skin and this increase correlates with disease severity and progression [187].
In correspondence with these in vitro observations, immunostaining for epidermal growth factor receptor was increased in human endometrial stromal cells undergoing decidualization in sections of secretory phase and first-trimester endometrial tissue.
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