The optic nerve sheath diameter (ONSD) may be increased in brain-injured patients, especially children, with intracranial hypertension.
Ubiquitin conjugates as well as elevated ubiquitin levels in our study were found to be increased in brains of experimental CT mice, indicating impairment of the UPS's processing of excess unwanted proteins [ 16].
Although there was large individual variation in humans, binding of [11C]PK11195 was increased in brain areas corresponding to different pathological processes in ongoing or recent clinical deficits.
An adverse role for HNE in the brain in obesity and the metabolic syndrome is suggested by studies showing that HNE levels are increased in brain cells with aging and Alzheimer's disease.
In order to elucidate the mechanism of brain targeting by GSH-PEG liposomes, we here demonstrate that the in vivo delivery of liposomal ribavirin is increased in brain extracellular fluid according to the extent of GSH conjugation onto the liposomes.
The lipid peroxidation markers malondialdehyde and F2-isoprostane are increased in brain tissue, serum, and CSF after TBI (Sparvero et al., 2010; Seifman et al., 2008; Hoffman et al., 1996) and are associated with poor clinical outcomes (Pilitsis et al., 2003; Kasprzak et al., 2001).
Macropain (PSMA7) is increased in brain, breast, and stomach cancer, and plays an important role in colorectal cancer progression providing a unique target for drug development.
Lipids and vesicle membranes were found in Lewy bodies on autopsy [63] and lipid-bound soluble cytosolic oligomers were increased in brain extracts from patients with Parkinson's disease or dementia with Lewy bodies [64].
Similarly, neurexin-CTFs levels are increased in brain lysates of both PS1−/− embryos and adult PS cDKO mice, confirming that neurexins are processed by PS/γ-secretase in vivo.
