Sentence examples for be increased by mutations from inspiring English sources
We used cellulase C from Clostridium thermocellum to test whether thermostability can be increased by mutations designed using rules learned from thermophilic proteins.
Similarly, the translational level of an enzyme can be increased by mutations that alter codon usage efficiency, mRNA stability, or ribosome binding strength.
Repeat-mediated recombinational activity can be increased by mutations in nuclear factors such as MSH1, OSB1, and RECA3, suggesting that SSS is under nuclear control (Zaegel et al. 2006; Shedge et al. 2007).
Here, we decided to test whether the protein-protein affinity could be increased by mutations not on the interface, but in cavities inside one of the cognate protein molecules.
For example, PARP-1-deficient mice exhibit increased spontaneous mammary carcinoma formation, the latency of which is increased by mutations in p53 [ 6].
Such coupling of longevity and stress resistance is not only observed when life span is increased by mutations but also when achieved by non-genetic interventions.
The instability of (CTG n CAG n repeats and the frequency of chromosome breakage are increased by mutations in yeast replisome proteins.
If overall genetic diversity is increased by mutations, these are considered to be predominantly deleterious [ 34, 35] and the lack of sexual reproduction leads to their accumulation with subsequent detrimental effect ("Muller's ratchet"; [ 36]).
Moreover, for all but IGF/INS, the phenomenon is reversed for pAKT: pErbB2 and basal pAKT levels (the latter of which can also be increased by PI3K/PTEN mutations, Additional file 8: Figure S4) are positively correlated with absolute pAKT levels following ligand treatment, but not with fold-change.
ROS are generated in cells as metabolic byproducts, the accumulation of which can be increased by environmental conditions, genetic mutations and cell ageing [ 14- 16].
Accuracy of single-, but especially multi-breed genomic prediction, could be increased by using sequence data, since the causative mutations are probably included in the dataset.
