Sentence examples for be inactivated by point from inspiring English sources

The integration of resequencing data, and epigenetic data, can facilitate the identification of tumour suppressor genes in regions of LOH, where the other allele may be inactivated by point mutation or epigenetic changes.

Among the 79 IGHV pseudogenes, 26 were inactivated by point mutations or other minor changes, and 53 which are about twice of those caused by point and minor mutations were caused by major structural changes with the majority by truncations.

Allelic loss, manifested as loss of heterozygosity (LOH) at polymorphic loci, is recognised as a hallmark of tumour suppressor genes, whose other allele is inactivated by point mutations or by some other mechanism (Knudson, 1985).

In various tumor types INK4a as a bona fide tumor suppressor undergoes homozygous deletions, is inactivated by point mutations, LOH or hypermethylation; p16INK4a expression is reduced or ceases under such conditions or the protein function may be impaired [ 18].

Several putative sugar transporters predicted to be functional in other Brucella species appear to be inactivated by frameshifts, point mutations or gene degradation in B. ovis.

APC gene may be inactivated by aberrant DNA methylation of CpG islands in their promoter regions.

Following the formation of catechol estrogen quinones (Fig. 2), they can be inactivated by reacting with glutathione (GSH).

Antibiotics can be inactivated by adsorption.

JNK may also be inactivated by IKK β.

Such apoptotic function could be inactivated by p53 mutations.

F1-ATPase tends to be inactivated by binding ADP tightly.