Sentence examples for be inactivated by a from inspiring English sources

TP53 could be inactivated by a variety of mechanisms including inactivating mutations, DNA loss and loss of mRNA expression.

Because FANCB is expected to be present as a single functional copy in most cells, it could potentially be inactivated by a single mutational event, distinct from the two-hit paradigm typical of most tumor-suppressor genes.

The ROMK (Kir1.1) family of epithelial K channels can be inactivated by a combination of low internal pH and low external K, such that alkalization does not reopen the channels unless external K is elevated.

The DNA preparation can be incubated at 37 degrees Celsius for at least 30 minutes in a thermal cycler or alternatively can be left at room temperature for the same duration, and the proteinase can be inactivated by a two-minute incubation at 95 degrees Celsius.

The objective of the present study was to analyze the NOTCH2 locus either as a chromosomal translocation locus that may be altered by the 1p/19q recurrent rearrangement or as a gene that may be inactivated by a two hit process.

A gene could be inactivated by a mutation either in a control site or in a coding region [ 47].

Geneticists discovered that one of their two copies of FOXP2 was inactivated by a mutation.

Here, a putative MspI endonuclease gene, ccel2866, was inactivated by a ClosTron-based gene disruption method.

The cystic fibrosis gene is actually a defective normal gene that has been inactivated by a mutation or a deletion of part of the gene.

Bradykinin is inactivated by a kininase, which also converts angiotensin I to angiotensin II, a substance that causes the constriction of blood vessels.

By providing information on the neuroplasticity of receptors expressed in a motoneuron pool that is inactivated by a higher-level spinal cord injury, appropriate pharmacological targets can be identified to alter motoneuron excitability.