TP53 could be inactivated by a variety of mechanisms including inactivating mutations, DNA loss and loss of mRNA expression.
FVII gene can be inactivated by disrupting the entire coding sequence for the mature FVII protein29,30.
APC gene may be inactivated by aberrant DNA methylation of CpG islands in their promoter regions.
"These molecules may not be inactivated by conventional autoclaves or other methods of disinfection or sterilization," he says.
That form of growth control appears to be inactivated by oncogenic expression or tumour suppression activity.
Telomeric control of cell life span appears to be inactivated by the expression of oncogenes (cancer-causing genes) or by the deactivation of tumour suppressor genes.
The JNK cascade can be inactivated by the MAPK phosphatase VHP-1, and vhp-1-null mutants cause an arrest in developmental growth at the early larval stage due to hyperactivation of the JNK pathway (Supplementary Fig. 1 17.
Following the formation of catechol estrogen quinones (Fig. 2), they can be inactivated by reacting with glutathione (GSH).
Protein kinase "C" can be inactivated by the interaction of selenometabolites (CH3SeO2H) with catalytic site of protein kinase C which can lead to inhibition of tumor growth [78].
Once at the plasma membrane, E-cadherin can also be inactivated by proteolytic cleavage or destabilized by phosphorylation of β-catenin [43].
The number of E. coli after resuspension of sediment reached to the initial numbers after 24 h and showed that it cannot be inactivated by alum.
