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They are said to be in linkage disequilibrium [85].
The genetic association found in the different studies may be in linkage disequilibrium with the causative locus, thereby leading to confounding of the results.
The markers do not need to be in linkage disequilibrium with any risk alleles.
Alternatively, the associated SNP may be in linkage disequilibrium with another yet undetected causal variant.
Yet, they may be in linkage disequilibrium with an unknown causative variant.
The T102C polymorphism might be in linkage disequilibrium with the true functional variant [13].
Thus, it seems likely that any true causal variant(s) will be in linkage disequilibrium with rs2191249 or rs4988344.
The MHC microsatellites used here are known to be in linkage with MHC Class I, II, and III genes [67].
Thus, the rs7081735, located in the 5' untranslated region, could be the causal variant, or be in linkage disequilibrium with an unknown causal mutation.
In the first stage, microsatellites were typed in the 17q11.2 region, previously independently found to be in linkage with MS. One significant association was found at microsatellite D17S798.
Our findings lay the foundation for selecting additional genes to study that may be in linkage disequilibrium with the SNPs that we found to be associated with TT.
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