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Some structures have crystallized in catalytically active conformations, whereas others appear to be in inactive or native conformations.
The results for SLEDAI were consistent with SLE patient visits treated with HCQ (P = 0.0002; likelihood ratio: 13.9) or with MMF (P <0.0001; likelihood ratio: 16.1) were more likely to be in inactive states.
Using the wild-type GH receptor and the EED to KKR charge reversal receptor construct either separately or together, it was possible to ensure that essentially all of the receptors would be in inactive State 1 (when wild-type or KKR mutant were expressed alone) or consist of a subset of active State 2 receptors (when co-expressed).
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The Case I occurs when all UEs connected to the FAPs are in inactive state.
Bb consists of a von Willebrand factor type A (vWFA) domain that is structurally similar to the I domains of integrins and a serine protease (SP) domain that is in inactive conformation.
Of those 54 patients in our study, 36 cases were in active SLE group and 18 cases were in inactive SLE group.
Interestingly, these crystal structures also revealed that these catalytic domains were in inactive conformations before ubiquitin binding, suggesting alternative targets for drug design.
K-Ras in nuclei, if present, should be in its inactive form (not attached to Raf-RBD).
The strongest expression shifts could be identified in inactive animals compared to active animals.
These results imply that most H3K4/K27me3 genes encoding signaling and developmental functions in the ICM are in an inactive state.
Under normoxic environments, IL-10−/− macrophages are in an inactive, non-polarized state, and thus do not affect HMVEC proliferation.
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