Indeed, exoskeletons are in direct interaction with the human limb and even if it is possible to identify the nominal dynamics of the exoskeleton, the subject's limb dynamics remain typically unknown and defer from a person to another.
Nonetheless, the residues of the DBD that are in direct interaction with the DNA counterpart as revealed by the crystal structure of E. coli CRP/DNA complex [ 39], are highly conserved in all these cyanobacterial CRP sequences, suggesting that they might bind to similar DNA sequences.
This suggests that >90% of the functionally informative co-evolutionary connections are between genes that may not be in direct physical interaction (as determined by their relatively low PPI score).
Pertinent to this, the equivalent regions (and their vicinity) in HSCARG and NmrA have been shown in biochemical and structural studies to be involved in direct interaction with their protein-binding partners (see Supplementary Figure S5 at http://www.biochemj.org/bj/452/bj4520027add.htm) [ 44, 45].
Located at the extracellular end of transmembrane domain 1 of PMAT, I89 may occupy an important position close to the substrate permeation pathway and may be involved in direct interaction with the vasodilator dilazep.
In contrast to TβRI which mainly is important for signal transduction, TβRII is involved in direct interaction with the ligands TGF-β1, TGF-β2 and TGF-β3 [ 1].
On this basis it was hypothesized that the heptad repeat of β1a is involved in direct interaction with RyR1 [20,22] and thus plays an active role in the signal transduction from DHPR to RyR1 via β1a.
Our present coculture system was a real-time stimulation, which showed on the other way that FoxP3 expression was increased in direct interaction more than in indirect one.
Though the carboxy 28 residues were used for the study, only the last 13 residues of EBDs form an amphipathic α-helix and are involved in direct interaction with the FERM domain.
A highly sensitive impedimetric bio-chip based on vertically aligned multiwall carbon nanotubes (VAMWCNTs), was applied in direct interaction with lung cancer cells.
