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Two SNPs were genotyped and proven to be in complete linkage disequilibrium (D′ = 1.00, r2 = 1.00) and thus showed comparable results of disease association, which were reproduced in two panels collected independently.
The SNP +72C was not examined, since previous work [ 16] revealed it to be in complete linkage with the codon 25 SNP.
The +183 A/G polymorphism is reported to be in complete linkage disequilibrium (LD) with the 5'UTR -105C/T polymorphism, both being parts of 6 major haplotypes defined by 5 polymorphisms in the IL-18 gene [ 15].
Two single nucleotide polymorphisms (SNP), rs4341 and rs4343, previously found to be in complete linkage disequilibrium with the ACE I/D polymorphism were selected to design polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) [ 24].
Because MMP-8+17C>G and MMP-8−381A>G MMP-8−381A>Go be in complete linkage disequilibrium, wereecided to study the distribution ofound-8–799C>to MMP-8+17C>G in our group of gastric cancer patients.
The second SNP rs1544223 was not genotyped as it was found to be in complete linkage disequilibrium (LD) with rs1544224 in the subset of patients sequenced and almost complete LD (r2 = 0.974) in analysis of Utah residents with Northern and Western European ancestry (CEU) and Tuscan in Italy (TSI) from the HapMap Project.
Similar(52)
The two polymorphisms were in complete linkage disequilibrium.
The A allele of the rs1042717 G/A polymorphism is in complete linkage disequilibrium with the CysGlyGln haplotype of ADRB2; therefore, rs1042717 was genotyped.
The p73 G4C14-to-A4T14 dinucleotide polymorphism, consisting of two single-nucleotide polymorphisms in the non-coding region of exon 2 that are in complete linkage disequilibrium, has been extensively studied in association with cancer risk.
Both CRP rs1130864 and rs1417938 polymorphisms were in complete linkage disequilibrium (LD) in our study subjects and hence only CRP rs1130864 and rs1205 polymorphisms (the latter not in LD with the former) were taken into consideration in further analyses.
The APOE –219G>T and Arg158Cys as well as the Arg158Cys and Cys112Arg polymorphisms were in complete linkage disequilibrium (D' = 1.0).
More suggestions(17)
be in relative linkage
be in complete remission
be in complete compliance
be in complete support
be in perfect linkage
be in complete opposition
be in high linkage
be in close linkage
be in complete accord
be in complete agreement
be in full linkage
be in intragenic linkage
be in complete shock
be in complete lock
be in complete contact
be in complete disarray
be in significant linkage
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