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It is pertinent to note at this point that imputation using chained equations does not require the variables to be imputed in a specific order.
Also, our unified modeling framework will allow us to combine information from the entire cohort, as individual-level exposures that may not exist in the larger cohort study but are present in the pilot study can be imputed in a way that fully utilizes all available covariate information.
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The genotypes at more than 17 million positions can now be imputed in any animal of the Fleckvieh breed with array-derived medium or high density genotypes.
Missing values were imputed in a similar way as described above for cortisol levels.
GA was imputed in a regression model based on birth weight, parity, per capita family income, and newborn's sex.
Some observations in all cohorts except ELFE and HUMIS were missing lipid-adjusted concentrations, and these were imputed in a cohort-specific model including wet-weight concentrations.
In the MI process, all of these variables were imputed in a coherent process, using the Markov chain Monte Carlo (MCMC) method.
Similar to our previous study [ 17], missing cost data was imputed in a last-observation-carried-forward manner, and all costs were extrapolated to a 12-month period.
However, using IMPUTE2, we observed that accuracy was slightly higher when the whole chromosome was imputed in a single run (not shown).
Data were imputed in a two-stage procedure, using SHAPEIT to derive phased genotypes and IMPUTE version 2 (IMPUtov2) to perform the imputation on the phased data [ 21].
At the end, gestational age was imputed in a regression model based on birth weight, parity, per capita monthly family income, and newborn's sex.
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