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Note that unlike traditional missing data imputation approaches (in which the missing cholesterol of those on treatment would be imputed based on the observed cholesterols of other participants at the same exam who were untreated), we are using an independent subset of new-users with pre- and post- treatment values to develop the imputation model.
Price data used in primary studies are not obtained from survey respondents and must be imputed based on respondents' place of residence (state or city).
Table 1 shows the categories for those common SNPs with known functional annotations (dbSNP v129) or those that could be imputed based on their neighboring SNPs (Supplemental Table S2 for all SNPs).
Consequently, while rs1800795 analysis failed for four patients, two SNPs could be imputed based on rs1800797.
These missing values will be imputed based on the baseline characteristics of the practice and individual [ 34].
Missing prognostic and EQ-5 D data will be imputed, based on each patient's other prognostic characteristics.
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Finally, missing observations were imputed based on proximate years using a custom multiple-imputation algorithm [ 14].
Where general practices did not give consent to provide data, scores were imputed based on the available hospital data using single linear imputation on the logit scale.
Missing post-baseline scores were imputed based on last observation carried forward (LOCF) or based on the multiple imputation approach if data were not available for LOCF for the third primary efficacy endpoint.
1Mortality is imputed based on NHIS-NDI data. 2 Internal Migration is imputed based on the March CPS.
*=restriction is based on grade completion (ages are imputed based on scheduled school progression).
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