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Excessive daytime sleeping is associated with poorer functional outcomes in rehabilitation populations and may be improved with targeted interventions.
Further work should explore how performance can be improved with targeted rehabilitation.
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Indeed, the outlook of patients with CLL is improving with the advent of targeted therapies, including second-generation monoclonal antibodies, immune modulators, BTK inhibitors, PI3K inhibitors and BCL2 antagonists.
1 The prognosis of patients with metastatic RCC is improving with the introduction of molecular-targeted therapy.
Previous clinical studies in Europe and the USA suggested that the prognosis of patients with metastatic RCC was improving with the introduction of molecular-targeted therapy.
While it is evident that targeted agents can prove effective as monotherapy, the question is whether this efficacy can be improved upon with combination regimens.
Motivation: The probability of effective treatment of cancer with a targeted therapeutic can be improved for patients with defined genotypes containing actionable mutations.
Cytology from endoscopic retrograde cholangiopancreatography (ERCP) brushings fails to demonstrate malignancy in 50% of cases, owing to the desmoplastic nature of CCA (Khan et al., 2005); this can be improved to 40-70% by combining with targeted biopsies using cholangioscopy in specialist centres (Khan et al., 2012).
If breastfeeding initiation rates are to be improved beyond the current rate, targeted strategies are required.
Our results indicate that the methodology can still be improved, in particular, with respect to probe design, obtaining a more even coverage of the targeted regions.
With the implementation of new targeted regulations, reimbursement strategies, and drug approvals, accessibility to treatment will be improved for people afflicted with rare diseases in these developing countries.
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