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Unfortunately, CT and PET scans are very expensive, Barry acknowledges, and it would be impractical to screen the more than 2 billion people, most of them in poor countries, who meet the definition of latent TB.
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Therefore, it is impractical to screen all possible combinations by conventional experiments or empirical rules.
However the large number of possible combinations (20=64×10) is impractical to screen.
High-throughput screening is useful to identify possible drug combinations; however, it is impractical to screen all possible drug combinations for all possible indications.
It is impractical to screen all possible drug combinations experimentally since there will be an exponential explosion when the number of single drugs increases.
When disease risk alleles are relatively common in a population, then screening all individuals may be cost effective, but when the risk allele is rare, then it is impractical to screen everyone [ 42, 43].
Although it is impractical to screen every athlete during large events, organisers are encouraged to provide information, possibly in registration kits, advising all athletes of the risk associated with participation under various potential compromised states and suggesting countermeasures.
Indeed, the amount of extract produced was often so drastically smaller than those produced by solid media cultures, that for a drug-discovery screening program, it would be impractical to use liquid cultures as a standard culture procedure; isolating sufficient quantities of compounds of interest would be challenging.
It may also be impractical to detail all alternatives (e.g., every possible screening frequency or combination of tests).
These would be impractical to analyse manually.
However, the lack of isogenic strains for comparison is a disadvantage when the strain has potentially novel VISA-causing mutations because it is impractical to attempt to screen the large number of candidate loci by current genetic reconstruction techniques.
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