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One major limitation of the parametric g-formula is the "g-null paradox," which states that under the causal null hypothesis it may be impossible to correctly specify the models for the g-formula, and as a consequence the causal null hypothesis will be rejected when it is in fact true.
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This example was taken from analysis at a genus level of novelty, where all other genera within the same family are excluded, and the taxonomic assignment was at the family level (as it was impossible to correctly assign to the genus level).
For this reason, it is impossible to correctly determine the Curie point for this sample.
In some cases, due to severe occlusion, it is impossible to correctly detect the tomatoes even manually.
EDX scan of the cross section was attempted as well, but it was impossible to correctly focus the 1-μm electron beam on the non-flat surface of the agglomerates.
With this type of artefact, it is impossible to correctly classify the image using a global threshold even after NAD filtering, no matter how sophisticated the selection algorithm may be.
It's impossible to correctly gauge what proportion of British buyers of sex work use the internet, let alone UKPunting, as a resource, but according to recent Home Office figures 72,000 people in England and Wales are sex workers.
However, as the overlap in T-cell frequencies between the groups was substantial, it was impossible to correctly assign the patients' clinical status on an individual basis (area under the curve AUC = 0.63, 95% confidence interval (CI) 0.46 to 0.79).
An erroneously enciphered text can be impossible to interpret correctly, and it is difficult to recognize a mistake without a double-check.
The SOS response only takes effect when DNA damage is so extensive that it may be impossible to use undamaged template strands to correctly re-synthesize damaged portions of the genome.
If context and provenance information for a primary study are inaccessible, it may be impossible to reuse the study's data correctly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com